Our team focuses on neurobiological engineering of next-generation molecular sensors and actuators for functional imaging and remote spatiotemporal control of cellular processes.
We apply these molecular devices for dynamic analyses of organoids and neurobehavioral imaging of preclinical model organisms to dissect cellular network function and aid future imaging-controlled regenerative and cell therapies.
We develop new genetically controlled molecular sensors that can map dynamic signaling processes across multiple scales ranging from volume Electron Microscopy via fluorescence imaging to non-invasive imaging methods such as multispectral optoacoustic tomography (MSOT) or MRI.
We build biophysical interfaces to exert spatiotemporal control over molecular processes. We are particularly interested in complementing optogenetic methods with genetically controlled molecular actuators responsive to magnetic gradients and advanced gene editing techniques.
We deploy our genetically controlled devices with hIPSC-derived cerebral organoids and animal models to bridge optophysiology with ultrastructural volume analysis.